Molecular pharmacology exam 2


Question 1.

Which of the following is not a drug intracellular target?

  • a) Enzyme
  • b) Protein synthesis
  • c) Ion channels
  • d) Nuclear receptors

Question 2.

Which of the following correctly matches a drug target to it’s method of inhibition

  • a) Receptors: Blockers
  • b) Ion channels: Agonists
  • c) Carrier molecules: Uncouplers
  • d) Enzymes: False substrates

Question 3.

True or false:

Thermodynamics is the study of what a drug does to the body and pharmacokinetics is the study of what the body does to the drug.

Question 4.

Which of the following factors doesn’t determine whether a drug is a ‘good’ drug

  • a) A range of off target effects making it suitable for treating a range of diseases
  • b) It is cheap to manufacture
  • c) It has a high bioavalability
  • d) Non-toxic
  • e) Effective at treating the disease

Question 5.

A drug with a pKa value of 4.5 is in the stomach with a pH of 3.5. What percentage of the drug will be ionized?

  • a) 91%
  • b) 90%
  • c) 10%
  • d) 9%

Question 6.

True or false:

The purified stereoisomer of a drug is usually just as effective then a racemic mixture of the drug

Question 7.

Below is the residue found on the amino acid threonine, which of the following is not a chemical bonding it would participate in.

  • a) Hydrogen bonding
  • b) Hydrophobic
  • c) Ion- dipole
  • d) Ion- pi interactions

Question 8.

Arrange bond strength in increasing order

  • i) Ionic bond
  • ii) Hydrogen bond
  • iii) Covalent bond
  • iv) dipole-dipole
  • V) Hydrophobic bond

Question 9.

The bonding between between ACh and AChE, as seen below, are:

  • a) Ionic at the anionic site
  • b) Dipole-dipole
  • c) Ion-dipole at the anionic site
  • d) Covalent since ACh is an antagonist for AChE

Question 10.

Select the True statement:

  • a) ACh is able to bind to both mAChR and nAChR since they are both have the same shape active sites
  • b) ACh is able to bind to both mAChR and nAChR since it can change its conformation to fit into both of the active sites


  1. c
  2. d – receptors should be agonists, antagonists or modulators – ion channels should be blockers or modulators – carrier molecules should be blockers or false substrates enzymes can be both false substrates and inhibitors
  3. False – should be pharmodynamics not thermodynamics
  4. a
  5. d
  6. False, usually more effective
  7. d
  8. iii, i, ii, iv, v
  9. c
  10. b

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