Questions.
Question 1.
Which of the following is not a drug intracellular target?
- a) Enzyme
- b) Protein synthesis
- c) Ion channels
- d) Nuclear receptors
Question 2.
Which of the following correctly matches a drug target to it’s method of inhibition
- a) Receptors: Blockers
- b) Ion channels: Agonists
- c) Carrier molecules: Uncouplers
- d) Enzymes: False substrates
Question 3.
True or false:
Thermodynamics is the study of what a drug does to the body and pharmacokinetics is the study of what the body does to the drug.
Question 4.
Which of the following factors doesn’t determine whether a drug is a ‘good’ drug
- a) A range of off target effects making it suitable for treating a range of diseases
- b) It is cheap to manufacture
- c) It has a high bioavalability
- d) Non-toxic
- e) Effective at treating the disease
Question 5.
A drug with a pKa value of 4.5 is in the stomach with a pH of 3.5. What percentage of the drug will be ionized?
- a) 91%
- b) 90%
- c) 10%
- d) 9%
Question 6.
True or false:
The purified stereoisomer of a drug is usually just as effective then a racemic mixture of the drug
Question 7.
Below is the residue found on the amino acid threonine, which of the following is not a chemical bonding it would participate in.
- a) Hydrogen bonding
- b) Hydrophobic
- c) Ion- dipole
- d) Ion- pi interactions
Question 8.
Arrange bond strength in increasing order
- i) Ionic bond
- ii) Hydrogen bond
- iii) Covalent bond
- iv) dipole-dipole
- V) Hydrophobic bond
Question 9.
The bonding between between ACh and AChE, as seen below, are:
- a) Ionic at the anionic site
- b) Dipole-dipole
- c) Ion-dipole at the anionic site
- d) Covalent since ACh is an antagonist for AChE
Question 10.
Select the True statement:
- a) ACh is able to bind to both mAChR and nAChR since they are both have the same shape active sites
- b) ACh is able to bind to both mAChR and nAChR since it can change its conformation to fit into both of the active sites
Answers.
- c
- d – receptors should be agonists, antagonists or modulators – ion channels should be blockers or modulators – carrier molecules should be blockers or false substrates enzymes can be both false substrates and inhibitors
- False – should be pharmodynamics not thermodynamics
- a
- d
- False, usually more effective
- d
- iii, i, ii, iv, v
- c
- b