Molecular pharmacology exam 2

Questions.

Question 1.

Which of the following is not a drug intracellular target?

  • a) Enzyme
  • b) Protein synthesis
  • c) Ion channels
  • d) Nuclear receptors

Question 2.

Which of the following correctly matches a drug target to it’s method of inhibition

  • a) Receptors: Blockers
  • b) Ion channels: Agonists
  • c) Carrier molecules: Uncouplers
  • d) Enzymes: False substrates

Question 3.

True or false:

Thermodynamics is the study of what a drug does to the body and pharmacokinetics is the study of what the body does to the drug.

Question 4.

Which of the following factors doesn’t determine whether a drug is a ‘good’ drug

  • a) A range of off target effects making it suitable for treating a range of diseases
  • b) It is cheap to manufacture
  • c) It has a high bioavalability
  • d) Non-toxic
  • e) Effective at treating the disease

Question 5.

A drug with a pKa value of 4.5 is in the stomach with a pH of 3.5. What percentage of the drug will be ionized?

  • a) 91%
  • b) 90%
  • c) 10%
  • d) 9%

Question 6.

True or false:

The purified stereoisomer of a drug is usually just as effective then a racemic mixture of the drug

Question 7.

Below is the residue found on the amino acid threonine, which of the following is not a chemical bonding it would participate in.

  • a) Hydrogen bonding
  • b) Hydrophobic
  • c) Ion- dipole
  • d) Ion- pi interactions

Question 8.

Arrange bond strength in increasing order

  • i) Ionic bond
  • ii) Hydrogen bond
  • iii) Covalent bond
  • iv) dipole-dipole
  • V) Hydrophobic bond

Question 9.

The bonding between between ACh and AChE, as seen below, are:

  • a) Ionic at the anionic site
  • b) Dipole-dipole
  • c) Ion-dipole at the anionic site
  • d) Covalent since ACh is an antagonist for AChE

Question 10.

Select the True statement:

  • a) ACh is able to bind to both mAChR and nAChR since they are both have the same shape active sites
  • b) ACh is able to bind to both mAChR and nAChR since it can change its conformation to fit into both of the active sites

Answers.

  1. c
  2. d – receptors should be agonists, antagonists or modulators – ion channels should be blockers or modulators – carrier molecules should be blockers or false substrates enzymes can be both false substrates and inhibitors
  3. False – should be pharmodynamics not thermodynamics
  4. a
  5. d
  6. False, usually more effective
  7. d
  8. iii, i, ii, iv, v
  9. c
  10. b

Leave a Reply

Get emailed the detailsMaking learning enjoyable, earn gift cards for studying
Homework emailed to you weeklyNever fall behind with physics, biology, chemistry, science extension and mathematics homework

Subscribe below to get homework emailed to you each week for free!

Join 27,053 other students getting ahead