Author Archives: Joshua Mills

16 marks – 25 mins Questions. Question 1. [2 marks] 2 charged particles are 30 cm apart, if one has a charge of +4 V/m and -3 V/m, what is the force of attraction Question 2. [3 marks] Using a diagram, explain what will happen when two wires running parallel to one another have aContinue reading “Electromagnetism module review”

Question 1. How many ways can the word banana be rearranged so that all the a’s are together. Question 2. Solve for n n+1P4 = 32760 Question 3. Solve for n nC4 =5 nC3 Question 4. Expand (4x – 1/(x))^5 Question 5. A group of 15 people are waiting to enter a dinner, 4 areContinue reading “Permutations, combinations and polynomials module exam”

10 marks Question 1. The first pass principle can be described as a) The drug which is metabolized and excreted before it reaches systemic circulation b) The drug which reaches the portal vein and passes through the liver c) The drug which is metabolized by CYPs in the intestine and doesn’t reach circulation d) ExhalingContinue reading “Pharmacokinetics Exam”

Chromatography – involves solvent separation on a solid medium and uses the different rate of movement of the solvent Decanting – separating a liquid from a solid/liquid by pouring out the top layer leaving the unwanted layer behind Distillation takes advantage of differences in boiling points allowing for liquids to be separated. For example water and foodContinue reading “Year 11 Separating Techniques”

Learn. All plants and animals are composed of cells. These cells have a common form. These are eukaryotic cells – meaning they contain membrane bound organelles. Animal cell Plant cell Organelles & features common to both animal and plant cells Organelle/ feature Function Nucleus The nucleus stores and organizes the genetic information of the cellContinue reading “Animal cell vs plant cell”

G protein second messenger cascade Physiological antagonists Intrinsic activity of receptors Receptor desensitization Orthosteric and allosteric Learn. Recall that a muscarinic ACh receptor is a g coupled-protein receptor. These have seven proteins which go into and out of the cell and allow the ‘outside’ signals to be passed inside the cell. These then form secondaryContinue reading “Drug action targets”

Concentration effect curves for competitive agonists (reversible/ surmountable, non-reversible). Non-competitive inhibition (irreversible, allosteric, physiological antagonist) Reversible competitive antagonists dissociation constant Schild plot and the antagonist dissociation constant Antagonist KB is independent of agonist affinity, efficacy, and potency IC50 is potency, this is half the concentration of the antagonist which is required to reduce a maximalContinue reading “Antagonists”

Agonist, antagonist Law of mass action Drug concentration, binding affinity, receptor number, antagonist Hill-Langmuir equation Direct binding experiments Potency – ED50 & pD2 Cooperativity Intrinsic activity Partial Agonists Learn. Agonists are both endogenous and exogenous – these are small molecules which form an agonist receptor complex resulting in the activation of the receptor. Agonists areContinue reading “Agonists”

Learn. An expression is a mathematical function which is not equating something. For example: 3x + 4y + 2 An equation is a mathematical function which is saying this is equal to this. For example: 3x + 4y + 2 = 3 Master. Question 1. Simplify the following: a) 2x + 3y + 4x b)Continue reading “Expression vs equations”

Anecdote  “This was the start of my life… I had no idea what I wanted to do… I dropped out” Following intuition and curiosity Beautiful, suttle… in a way science can’t capture Humour  Windows just copied the mac Metaphor, direct narration “You”, repetition It was impossible to connect the dots looking forward… Again, You can’tContinue reading “Steve Jobs Commencement speech”