Molecular pharmacology exam 2

Questions. Question 1. Which of the following is not a drug intracellular target? a) Enzyme b) Protein synthesis c) Ion channels d) Nuclear receptors Question 2. Which of the following correctly matches a drug target to it’s method of inhibition a) Receptors: Blockers b) Ion channels: Agonists c) Carrier molecules: Uncouplers d) Enzymes: False substratesContinue reading “Molecular pharmacology exam 2”

The human digestive System

Learn. Master. Question 1. Outline the flow of food from your mouth to excretion Question 2. What is absorbed in the small intestine Question 3. The small intestine is lined with micro villi, linking back to the SA:V ratio concept. Explain the importance of this. Question 4. How does the stomach provide both chemical andContinue reading “The human digestive System”

Permutations, combinations and polynomials module exam

Question 1. How many ways can the word banana be rearranged so that all the a’s are together. Question 2. Solve for n n+1P4 = 32760 Question 3. Solve for n nC4 =5 nC3 Question 4. Expand (4x – 1/(x))^5 Question 5. A group of 15 people are waiting to enter a dinner, 4 areContinue reading “Permutations, combinations and polynomials module exam”

Pharmacokinetics Exam

10 marks Question 1. The first pass principle can be described as a) The drug which is metabolized and excreted before it reaches systemic circulation b) The drug which reaches the portal vein and passes through the liver c) The drug which is metabolized by CYPs in the intestine and doesn’t reach circulation d) ExhalingContinue reading “Pharmacokinetics Exam”

Year 11 Separating Techniques

Chromatography –¬†involves solvent separation on a solid medium and uses the different rate of movement of the solvent Decanting – separating a liquid from a solid/liquid by pouring out the top layer leaving the unwanted layer behind Distillation¬†takes advantage of differences in boiling points allowing for liquids to be separated. For example water and foodContinue reading “Year 11 Separating Techniques”

Animal cell vs plant cell

Learn. All plants and animals are composed of cells. These cells have a common form. These are eukaryotic cells – meaning they contain membrane bound organelles. Animal cell Plant cell Organelles & features common to both animal and plant cells Organelle/ feature Function Nucleus The nucleus stores and organizes the genetic information of the cellContinue reading “Animal cell vs plant cell”

Drug action targets

G protein second messenger cascade Physiological antagonists Intrinsic activity of receptors Receptor desensitization Orthosteric and allosteric Learn. Recall that a muscarinic ACh receptor is a g coupled-protein receptor. These have seven proteins which go into and out of the cell and allow the ‘outside’ signals to be passed inside the cell. These then form secondaryContinue reading “Drug action targets”

Antagonists

Concentration effect curves for competitive agonists (reversible/ surmountable, non-reversible). Non-competitive inhibition (irreversible, allosteric, physiological antagonist) Reversible competitive antagonists dissociation constant Schild plot and the antagonist dissociation constant Antagonist KB is independent of agonist affinity, efficacy, and potency IC50 is potency, this is half the concentration of the antagonist which is required to reduce a maximalContinue reading “Antagonists”