Understanding peptides: Chemical biology

Recent Advances in Peptide Therapeutics

• TB500
• BPC157
• Peptide delivery: Break-throughs to get us to the other side.

Synthesis of Peptides

• Natural and unnatural amino acids
  • The 20 natural amino acids
    • The chemistry of amino acids
  • Strecker synthesis of alanine
  • Non-canonical amino acids: Going beyond the natural
• Synthetic Peptides
  • Fmoc Solid Phase Peptide Synthesis
    • Pep-Man: A Peptide Synthesis Game
  • Boc Solid Phase Peptide Synthesis
  • Solution Phase Peptide Synthesis
  • Automated Peptide Synthesis
• How nature makes peptides
  • The central dogma
  • Genetic code expansion

Chemical bonding for peptides

• The chemistry of the peptide bond
• Bioconjugation reactions
• Bioorthoganal and click reactions
• Chemical Ligation

Characterisation of Peptides

• Flash Chromatography
• Reverse-Phase Separation of peptides
  • LCMS

How new peptides are discovered

• Phage display
• RAPID mRNA Screening
• Natural product extracts

Chemistry background knowledge:

• Organic chemistry & curly arrow notation notation
• Functional groups
• Classification of organic reactions (addition, elimination, substitution, redox, acid/base)
• Isomers
  • Stereoformula
    • Fischer projection
• Kinetics and thermodynamics
• Fischer

Other Peptide Blogs

• Biotage